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Integrative omics analysis identifies macrophage migration inhibitory factor signaling pathways underlying human hepatic fibrogenesis and fibrosis
- Source :
- Journal of bio-X research, Journal of Bio-X Research, Vol 2, Iss 1, Pp 16-24 (2019)
- Publication Year :
- 2019
-
Abstract
- The genetic basis underlying liver fibrosis remains largely unknown. We conducted a study to identify genetic alleles and underlying pathways associated with hepatic fibrogenesis and fibrosis at the genome-wide level in 121 human livers. By accepting a liberal significance level of P
- Subjects :
- lcsh:R
lcsh:Medicine
Single-nucleotide polymorphism
Quantitative trait locus
Biology
medicine.disease
Article
pathway enrichment analysis
alpha-smooth muscle actin
lcsh:Biology (General)
Fibrosis
Gene expression
medicine
Genetic predisposition
Cancer research
genomics
macrophage migration inhibitory factor
Macrophage migration inhibitory factor
hepatic fibrosis
Allele
Hepatic fibrosis
lcsh:QH301-705.5
genetic susceptibility
Subjects
Details
- Language :
- English
- ISSN :
- 25773585 and 20965672
- Volume :
- 2
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of bio-X research
- Accession number :
- edsair.doi.dedup.....4a98d8dbdbe955cf6fd968b66e3edf28