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Determinants of Malaria Protective Immunity in Mice Immunized with Live Sporozoites during Trimethoprim–Sulfamethoxazole Prophylaxis
- Source :
- The American Journal of Tropical Medicine and Hygiene
- Publication Year :
- 2020
- Publisher :
- The American Society of Tropical Medicine and Hygiene, 2020.
-
Abstract
- HIV and malaria geographically overlap. Trimethoprim–sulfamethoxazole (TMP-SMX) is a drug widely used in HIV-exposed uninfected and infected children in malaria-endemic areas, and is known to have antimalarial effects. Further study in terms of antimalarial impact and effect on development of malaria-specific immunity is therefore essential. Using rodent malaria models, we previously showed that repeated Plasmodium exposure during TMP-SMX administration, or chemoprophylaxis vaccination (CVac), induces CD8 T-cell–dependent preerythrocytic immunity. However, humoral immune responses have been shown to be important in models of preerythrocytic immunity. Herein, we demonstrate that antibody-mediated responses contribute to protective immunity induced by CVac immune sera using TMP-SMX in models of homologous, but not heterologous, parasite species. Clinical studies must account for potential anti-Plasmodium antibody induced during TMP-SMX prophylaxis.
- Subjects :
- Plasmodium berghei
Heterologous
urologic and male genital diseases
Mice
Immune system
Immunity
Virology
parasitic diseases
Trimethoprim, Sulfamethoxazole Drug Combination
medicine
Animals
Mice, Inbred BALB C
biology
business.industry
Articles
Plasmodium yoelii
medicine.disease
bacterial infections and mycoses
Trimethoprim
female genital diseases and pregnancy complications
Malaria
Vaccination
Infectious Diseases
Sporozoites
Chemoprophylaxis
Immunology
biology.protein
Parasitology
Female
Immunization
Antibody
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 14761645 and 00029637
- Volume :
- 104
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The American Journal of Tropical Medicine and Hygiene
- Accession number :
- edsair.doi.dedup.....4a90929e65df96525214185c27e0c632