Back to Search
Start Over
Oropharyngeal microbiome of a college population following a meningococcal disease outbreak
- Source :
- Scientific Reports, Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Asymptomatic oropharyngeal carriage of Neisseria meningitidis peaks in adolescence and young adulthood. Following a meningococcal disease outbreak at a U.S. college, we profiled the oropharyngeal microbiomes of 158 students to identify associations between bacterial community composition and meningococcal carriage or risk factors for carriage, including male gender, smoking, and frequent social mixing. Metagenomic shotgun sequencing identified 268 bacterial taxa at the genus or species level, with Streptococcus, Veillonella, and Rothia species being most abundant. Microbiome composition showed weak associations with meningococcal carriage and risk factors for carriage. N. meningitidis abundance was positively correlated with that of Fusobacterium nucleatum, consistent with hypothesized propionic acid cross-feeding. Additional species had positive abundance correlations with N. meningitidis, including Aggregatibacter aphrophilus, Campylobacter rectus, Catonella morbi, Haemophilus haemolyticus, and Parvimonas micra. N. meningitidis abundance was negatively correlated with unidentified Veillonella species. Several of these species are commonly found in dental plaque, while N. meningitidis is primarily found in the pharynx, suggesting that ecological interactions extend throughout the oral cavity. Although risk factors for meningococcal carriage do not strongly impact most bacterial species in the oropharynx, variation in the upper respiratory tract microbiome may create conditions that are more or less favorable for N. meningitidis carriage.
- Subjects :
- Male
0301 basic medicine
lcsh:Medicine
Oropharynx
Neisseria meningitidis
medicine.disease_cause
Disease Outbreaks
Risk Factors
lcsh:Science
education.field_of_study
Multidisciplinary
biology
Microbiota
Smoking
Carrier State
Female
Adolescent
Universities
030106 microbiology
Population
Meningitis, Meningococcal
Meningococcal disease
Article
Microbiology
Veillonella
Young Adult
03 medical and health sciences
Sex Factors
medicine
Humans
Microbiome
Social Behavior
Students
Clinical microbiology
education
Parvimonas micra
lcsh:R
Streptococcus
Aggregatibacter aphrophilus
medicine.disease
biology.organism_classification
stomatognathic diseases
030104 developmental biology
Carriage
Microbial Interactions
lcsh:Q
Metagenomics
Fusobacterium nucleatum
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....4a8f79a56fe51fd2a55a0ba8dbfb04a2