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Chronic lithium treatment diminishes the female advantage in lifespan inDrosophila melanogaster
- Source :
- Clinical and Experimental Pharmacology and Physiology. 42:617-621
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Summary Two studies have concluded that lithium exposure extends the lifespan of Caenorhabditis elegans. However, the effect of lithium on another widely used model organism, Drosophila melanogaster, remains unclear. Here, we demonstrate that chronic treatment with a low to moderate dose of lithium chloride does not extend lifespan in D. melanogaster and that the drug abolishes the female lifespan advantage in flies.
- Subjects :
- Male
Lithium (medication)
Physiology
Longevity
ved/biology.organism_classification_rank.species
Biology
Drug Administration Schedule
chemistry.chemical_compound
Physiology (medical)
medicine
Animals
Model organism
Caenorhabditis elegans
Pharmacology
Genetics
Sex Characteristics
ved/biology
biology.organism_classification
Cell biology
Survival Rate
Drosophila melanogaster
Treatment Outcome
chemistry
Ageing
Lithium chloride
Female
Lithium Chloride
Chronic lithium
Moderate-Dose
medicine.drug
Subjects
Details
- ISSN :
- 03051870
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Pharmacology and Physiology
- Accession number :
- edsair.doi.dedup.....4a8af14093ba5ba217fc24f57a95aae8