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A Meta-Analysis of Obesity and Risk of Colorectal Cancer in Patients with Lynch Syndrome: The Impact of Sex and Genetics
- Source :
- Nutrients, Vol 13, Iss 1736, p 1736 (2021), Nutrients, Volume 13, Issue 5
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- There appears to be a sex-specific association between obesity and colorectal neoplasia in patients with Lynch Syndrome (LS). We meta-analyzed studies reporting on obesity and colorectal cancer (CRC) risk in LS patients to test whether obese subjects were at increased risk of cancer compared to those of normal weight. We explored also a possible sex-specific relationship between adiposity and CRC risk among patients with LS. The summary relative risk (SRR) and 95% confidence intervals (CI) were calculated through random effect models. We investigated the causes of between-study heterogeneity and assessed the presence of publication bias. We were able to retrieve suitable data from four independent studies. We found a twofold risk of CRC in obese men compared to nonobese men (SRR = 2.09<br />95%CI: 1.23–3.55, I2 = 33%), and no indication of publication bias (p = 0.13). No significantly increased risk due to obesity was found for women. A 49% increased CRC risk for obesity was found for subjects with an MLH1 mutation (SRR = 1.49<br />95%CI: 1.11–1.99, I2 = 0%). These results confirm the different effects of sex on obesity and CRC risk and also support the public measures to reduce overweight in people with LS, particularly for men.
- Subjects :
- Oncology
Adult
Male
Risk
medicine.medical_specialty
colorectal cancer
Overweight
Article
03 medical and health sciences
body weight
0302 clinical medicine
Sex Factors
lynch syndrome
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
TX341-641
030212 general & internal medicine
Obesity
Nutrition and Dietetics
business.industry
Nutrition. Foods and food supply
Cancer
Publication bias
medicine.disease
Colorectal Neoplasms, Hereditary Nonpolyposis
Lynch syndrome
030220 oncology & carcinogenesis
Meta-analysis
Relative risk
gender difference
Mutation
Female
medicine.symptom
business
Colorectal Neoplasms
MutL Protein Homolog 1
Body mass index
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 13
- Issue :
- 1736
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....4a880649859121afc7faa00c4c9b4081