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Prenatal and perinatal risk factors for solid childhood malignancies: A questionnaire-based study
- Source :
- Pediatric Investigation
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Importance: Childhood solid tumors account for the highest proportion of childhood cancers and are one of the leading causes of death in childhood. However, their pathogenesis is unclear. Objective: To explore prenatal and perinatal risk factors for solid malignancies in children. Methods: We enrolled 71 consecutive pediatric patients (44 boys and 27 girls; median age, 30 months) with solid tumors who were diagnosed and treated at our center from January 2013 to December 2016 as the case group. We also enrolled 211 age- and residence-matched healthy children (ratio of approximately 3:1 with the case group) as the control group. We conducted a questionnaire-based survey with the parents of these 282 children. Univariate and multivariate conditional logistic regression analyses of the collected data were performed. Results: Confirmed solid malignancies included neuroblastoma (n = 32), rhabdomyosarcoma (n = 18), retinoblastoma (n = 7), renal tumors (n = 3), and other tumors (n = 11). Risk factors for solid childhood tumors in the univariate analysis were the parents’ age, gravidity, parity, abortion history, vaginal bleeding, family history of malignancy, and prenatal use of folic acid or hematinics/iron supplements (P < 0.05), and those in the multivariate analysis were higher parity (odds ratio [OR], 2.482; 95% confidence interval [CI], 1.521–4.048), family history of malignancy (OR, 3.667; 95% CI, 1.679–8.009), and prenatal use of hematinics/iron supplements (OR, 2.882; 95% CI, 1.440–5.767). In contrast, use of prenatal folic acid was protective (OR, 0.334; 95% CI, 0.160–0.694). Interpretation: A family history of malignancy, use of prenatal hematinics/iron supplements, and higher parity are risk factors for solid childhood tumors, whereas use of prenatal folic acid is a protective factor. Key words: Case-control study; Children; Maternal; Perinatal; Risk factors; Solid malignancies
- Subjects :
- Case‐control study
0301 basic medicine
medicine.medical_specialty
Protective factor
Maternal
Perinatal
Malignancy
03 medical and health sciences
0302 clinical medicine
medicine
Vaginal bleeding
Family history
Rhabdomyosarcoma
Children
Univariate analysis
Obstetrics
business.industry
Case-control study
Odds ratio
Solid malignancies
medicine.disease
030104 developmental biology
Risk factors
030220 oncology & carcinogenesis
Pediatrics, Perinatology and Child Health
Original Article
medicine.symptom
business
Subjects
Details
- ISSN :
- 25742272
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Pediatric Investigation
- Accession number :
- edsair.doi.dedup.....4a8516c23ea4dcba2cb4d04a03507631