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Efficacy and safety of once-daily glycopyrronium in predominantly Chinese patients with moderate-to-severe chronic obstructive pulmonary disease: the GLOW7 study [Corrigendum]
- Source :
- International Journal of Chronic Obstructive Pulmonary Disease
- Publication Year :
- 2015
- Publisher :
- Dove Medical Press, 2015.
-
Abstract
- BACKGROUND Glycopyrronium is a once-daily (od) long-acting muscarinic antagonist for the maintenance treatment of chronic obstructive pulmonary disease (COPD). The GLOW7 study evaluated the efficacy and safety of od glycopyrronium 50 μg in predominantly Chinese patients with moderate-to-severe COPD. METHODS In this 26-week, multi-center, double-blind, placebo-controlled, parallel-group study, men and women ≥40 years with moderate-to-severe COPD were randomized to glycopyrronium 50 μg od or placebo (2:1). The primary objective was to confirm the significant improvement of trough forced expiratory volume in 1 second (FEV1) following 12 weeks of treatment with glycopyrronium compared with placebo. Secondary objectives included the effect of glycopyrronium on health status (St George's Respiratory Questionnaire), breathlessness (Transition Dyspnea Index), other lung function parameters, rescue medication use, and COPD exacerbations. Safety and tolerability were also evaluated. RESULTS Of the 460 patients randomized, 459 were included in the full analysis set (glycopyrronium, n=306; placebo, n=154; mean age 64.7 years; mean post-bronchodilator FEV1: 50.8% predicted); 425 (92.4%) completed the study. At Week 12, glycopyrronium signifcantly improved trough FEV1 with a least square means treatment difference of 141 mL (95% confidence interval 111 mL, 171 mL; P
- Subjects :
- Spirometry
Adult
Male
medicine.medical_specialty
Pathology
China
Time Factors
Exacerbation
Health Status
Philippines
Vital Capacity
India
Muscarinic Antagonists
International Journal of Chronic Obstructive Pulmonary Disease
Placebo
Severity of Illness Index
Drug Administration Schedule
Pulmonary Disease, Chronic Obstructive
Asian People
Double-Blind Method
Internal medicine
Forced Expiratory Volume
Surveys and Questionnaires
Severity of illness
Republic of Korea
medicine
Humans
Adverse effect
Lung
Aged
COPD
medicine.diagnostic_test
business.industry
General Medicine
Recovery of Function
Middle Aged
medicine.disease
Glycopyrrolate
Confidence interval
Bronchodilator Agents
Dyspnea
Treatment Outcome
Tolerability
Female
business
Corrigendum
Subjects
Details
- Language :
- English
- ISSN :
- 11782005 and 11769106
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- International Journal of Chronic Obstructive Pulmonary Disease
- Accession number :
- edsair.doi.dedup.....4a7b007fa34365865a1e6165c2491126