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Clearance of C4d deposition after successful treatment of acute humoral rejection in follow-up biopsies: a report of three cases
- Source :
- Transplant International. 17:177-181
- Publication Year :
- 2004
- Publisher :
- Frontiers Media SA, 2004.
-
Abstract
- Acute humoral rejection (AHR) is currently perceived as an immunological reaction against donor antigens mediated by complement-binding antibodies. C4d, a split product of complement activation and bound to endothelial cells of the peritubular capillaries, is used as a diagnostic marker for AHR. We report on three patients with biopsy-proven acute humoral rejection who were treated initially with plasmapheresis (PS). As two of the patients did not recover renal function, and biopsy showed persistent C4d staining after PS, immunoadsorption (IAS) was additionally performed on them. In all patients, renal function recovered, and follow-up biopsies in two patients showed complete disappearance of C4d, 29 days and 58 days after transplantation and only minimal residual C4d deposits in one patient 48 days after transplantation. We conclude that successful treatment of AHR is followed by complete resolution of serological and histological markers of AHR, displayed by the disappearance of C4d.
- Subjects :
- Adult
Graft Rejection
Male
Nephrology
Pathology
medicine.medical_specialty
Biopsy
medicine.medical_treatment
Peritubular capillaries
Internal medicine
Complement C4b
Humans
Medicine
Immunoadsorption
Immunosorbent Techniques
Transplantation
biology
medicine.diagnostic_test
business.industry
Plasmapheresis
Middle Aged
Kidney Transplantation
Peptide Fragments
medicine.anatomical_structure
Humoral immunity
biology.protein
Female
Antibody
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 14322277 and 09340874
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Transplant International
- Accession number :
- edsair.doi.dedup.....4a77b5ca3ae3f111c86e88a9f1551c20