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The evolution of vertebrate Toll-like receptors
- Source :
- Proceedings of the National Academy of Sciences of the United States of America. 102(27)
- Publication Year :
- 2005
-
Abstract
- The complete sequences of Takifugu Toll-like receptor (TLR) loci and gene predictions from many draft genomes enable comprehensive molecular phylogenetic analysis. Strong selective pressure for recognition of and response to pathogen-associated molecular patterns has maintained a largely unchanging TLR recognition in all vertebrates. There are six major families of vertebrate TLRs. This repertoire is distinct from that of invertebrates. TLRs within a family recognize a general class of pathogen-associated molecular patterns. Most vertebrates have exactly one gene ortholog for each TLR family. The family including TLR1 has more species-specific adaptations than other families. A major family including TLR11 is represented in humans only by a pseudogene. Coincidental evolution plays a minor role in TLR evolution. The sequencing phase of this study produced finished genomic sequences for the 12 Takifugu rubripes TLRs. In addition, we have produced >70 gene models, including sequences from the opossum, chicken, frog, dog, sea urchin, and sea squirt.
- Subjects :
- Takifugu rubripes
Sequence analysis
Pseudogene
Molecular Sequence Data
Receptors, Cell Surface
Takifugu
Evolution, Molecular
Species Specificity
Phylogenetics
biology.animal
Animals
Phylogeny
Genetics
Multidisciplinary
Concerted evolution
Membrane Glycoproteins
biology
Base Sequence
Models, Genetic
Toll-Like Receptors
Vertebrate
Computational Biology
Genomics
Sequence Analysis, DNA
Biological Sciences
biology.organism_classification
Toll-Like Receptor 1
Gene Components
Multigene Family
Vertebrates
TLR10
Subjects
Details
- ISSN :
- 00278424
- Volume :
- 102
- Issue :
- 27
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Accession number :
- edsair.doi.dedup.....4a77a3f3ca9e561ebb2381f1243fa509