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Analysis of immunogenicity of different protein groups from malaria parasite Plasmodium falciparum
- Source :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 12(8)
- Publication Year :
- 2012
-
Abstract
- It was observed that pressure of host immune system leads to diversifying selection (which can be measured in terms of pN/pS ratio). In this research we checked whether Plasmodium falciparum proteins containing experimentally evident epitopes from the IEDB database are subject to diversifying selection. We also investigated which life stage of this parasite and which proteins are subject to the strongest immune pressure. To answer these questions we used information about experimentally evident epitopes from P. falciparum, that interact with human immune system and sequences of different isolates of P. falciparum obtained from PlasmoDB. We confirmed the expectations that proteins containing IEDB epitopes are subject to stronger diversifying selection which is evidenced by higher pN/pS ratio. A stage characterized by the highest average pN/pS ratio is that of the sporozoite. The greatest fraction of putative antigens is also present at this stage. We also found that the sporozoite stage is particularly interesting for further analysis as it potentially contains the highest number of unidentified epitopes.
- Subjects :
- Microbiology (medical)
Models, Molecular
Databases, Factual
Proteome
Plasmodium falciparum
Protozoan Proteins
Biology
Microbiology
Polymorphism, Single Nucleotide
Epitope
Host-Parasite Interactions
Epitopes
Immune system
Antigen
PlasmoDB
Genetics
Parasite hosting
Animals
Humans
Immunogenetic Phenomena
Malaria, Falciparum
Selection, Genetic
Molecular Biology
Ecology, Evolution, Behavior and Systematics
Life Cycle Stages
Immunogenicity
biology.organism_classification
Virology
Infectious Diseases
Subjects
Details
- ISSN :
- 15677257
- Volume :
- 12
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
- Accession number :
- edsair.doi.dedup.....4a60575e9fbde96d5d4ad7134180c734