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Exploiting ontology graph for predicting sparsely annotated gene function

Authors :
ChengXiang Zhai
Sheng Wang
Hyunghoon Cho
Bonnie Berger
Jian Peng
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Department of Mathematics
Cho, Hyunghoon
Berger Leighton, Bonnie
Source :
Bioinformatics, Oxford University Press
Publication Year :
2015

Abstract

Motivation: Systematically predicting gene (or protein) function based on molecular interaction networks has become an important tool in refining and enhancing the existing annotation catalogs, such as the Gene Ontology (GO) database. However, functional labels with only a few (<br />National Institute of General Medical Sciences (U.S.) (Grant 1U54GM114838)

Details

ISSN :
13674811
Volume :
31
Issue :
12
Database :
OpenAIRE
Journal :
Bioinformatics (Oxford, England)
Accession number :
edsair.doi.dedup.....4a4e0289146b202767e85254fa43e4b1