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Vesiculopustular Eruption in Neonatal Transient Myeloproliferative Disorder
- Source :
- The Indian Journal of Pediatrics. 81:391-393
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Transient myeloproliferative disorder (TMD) typically presents with pancytopenia, hepatosplenomegaly, and immature circulating white blood cells, and affects approximately 10 % of neonates with Down syndrome. The authors report a neonate with Down syndrome who developed acute widespread pustular eruptions as a sign of TMD. The white blood cell counts on the first day of life were markedly elevated, with blasts seen on examination of the peripheral blood smear. And the patient was noted to have a few erythematous papules and pustules especially on the face. On the following days pathergy positive crusted papules and pustules were increased and spread to trunk and extremities. Skin biopsy specimens showed pustular dermatitis, with subcorneal vesiculopustules and perivascular inflammation in superficial dermis. These lesions improved parallel with the hematologic improvement within two weeks. The authors aim to alert clinicians about this uncommon cause of vesiculopustular eruption with the present illustrative case and review the literature.
- Subjects :
- Down syndrome
Pathology
medicine.medical_specialty
Myeloproliferative Disorders
Skin Diseases, Vesiculobullous
medicine.diagnostic_test
business.industry
Infant, Newborn
Hepatosplenomegaly
Erythematous papule
medicine.disease
Pancytopenia
medicine.anatomical_structure
Dermis
White blood cell
Pediatrics, Perinatology and Child Health
Skin biopsy
medicine
Pathergy
Humans
Female
Down Syndrome
medicine.symptom
business
Subjects
Details
- ISSN :
- 09737693 and 00195456
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- The Indian Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....4a47fe38d5d4fd22a190186028c49be7
- Full Text :
- https://doi.org/10.1007/s12098-013-1192-7