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Improved Dynamic Nuclear Polarization Surface-Enhanced NMR Spectroscopy through Controlled Incorporation of Deuterated Functional Groups

Authors :
Christophe Copéret
Anne Lesage
W. Trent Franks
Martin Schwarzwälder
Wolfram R. Grüning
Lyndon Emsley
Aaron J. Rossini
Alexandre Zagdoun
Matthew P. Conley
Moreno Lelli
Hartmut Oschkinat
ISA - Centre de RMN à très hauts champs
Institut des Sciences Analytiques (ISA)
Université Claude Bernard Lyon 1 (UCBL)
Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL)
Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Laboratory of Inorganic Chemistry
Leibniz Forschungsinstitut für Molekulare Pharmakolgie = Leibniz Institute for Molecular Pharmacology [Berlin, Allemagne] (FMP)
Leibniz Association
EU Marie-Curie IFF Fellowship (PIIF-GA-2010-274574)
SNF (SNF projeckt 200021_134775/1)
EQUIPEX contract ANR-10-EQPX-47-01
ETH Zurich.
European Project
Source :
Angewandte Chemie, Angewandte Chemie, 2013, 52 (4), pp.1222-1225. ⟨10.1002/anie.201208699⟩, Angewandte Chemie, Wiley-VCH Verlag, 2013, 52 (4), pp.1222-1225. ⟨10.1002/anie.201208699⟩
Publication Year :
2013
Publisher :
HAL CCSD, 2013.

Abstract

In a spin: The use of deuterated surface passivation agents is shown to restore dynamic nuclear polarization (DNP) surface-enhanced NMR signals that are reduced in substrates containing methyl groups, while still protecting sensitive sites on the surface (see picture). Furthermore, apolar groups such as [D9]-trimethylsiloxy (TMS) repel radicals (yellow) away from the surface, thus diminishing detrimental paramagnetic effects induced by radical proximity. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Details

Language :
English
ISSN :
00448249 and 15213757
Database :
OpenAIRE
Journal :
Angewandte Chemie, Angewandte Chemie, 2013, 52 (4), pp.1222-1225. ⟨10.1002/anie.201208699⟩, Angewandte Chemie, Wiley-VCH Verlag, 2013, 52 (4), pp.1222-1225. ⟨10.1002/anie.201208699⟩
Accession number :
edsair.doi.dedup.....4a362bf07dc7ac938df1114eddb3230d
Full Text :
https://doi.org/10.1002/anie.201208699⟩