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Tucumã ( Astrocaryum aculeatum ) prevents memory loss and oxidative imbalance in the brain of rats with hyperlipidemia

Authors :
Fernanda Licker Cabral
Alessandra G. Manzoni
Matheus H Jantsch
Maria Rosa Chitolina Schetinger
Jean L.G. da Silva
Daniela B.R. Leal
Viviane M. Bernardes
Daniela F. Passos
Guilherme Lopes Dornelles
Juliana Sorraila de Oliveira
Source :
Journal of Food Biochemistry. 45
Publication Year :
2021
Publisher :
Hindawi Limited, 2021.

Abstract

Hyperlipidemia generates deposition of lipids, inflammation, and oxidative damage in cells and tissues, including those of the brain. Tucumã (Astrocaryum aculeatum) fruits contain bioactive compounds with antioxidant and anti-inflammatory effects. We evaluated the action of Tucumã extract on memory and brain cortex redox balance in hyperlipidemic rats. For 30 days, Wistar rats received Tucumã extract (250 mg/kg). Then, hyperlipidemia was induced by intraperitoneal administration of Poloxamer-407. Twenty-four hours later, the object recognition index was measured. The animals were euthanized for sample collection 36 hr postinduction. Hyperlipidemic animals showed memory loss and an imbalance between reactive species and intrinsic antioxidants. We found that Tucumã prevented memory loss and protein and lipid oxidative damage and prompted a better antioxidant response in the cerebral cortex of rats with hyperlipidemia. These findings suggest a neuroprotective effect and nutraceutical potential of Tucumã. PRACTICAL APPLICATIONS: In the present work, we demonstrated that induced hyperlipidemia in rats caused memory loss and redox unbalance, both factors prevented by the administration of Tucumã (Astrocaryum aculeatum) extract. Two aims were fulfilled with these results. The first was to show that hyperlipidemia affected brain function through oxidative damage and concerned basic research. The second was to offer a therapy that prevented this harm and could be applied in the clinic. Tucumã has ethnopharmacological importance through the consumption of fruits or the administration of extracts and oils by a population that was shown to enjoy improved health and longevity. Here, we show evidence that Tucumã contributes to the maintenance of brain health by preventing memory loss and oxidative damage, a nutraceutical supplement that may aid the prevention of vascular, inflammatory, and brain diseases.

Details

ISSN :
17454514 and 01458884
Volume :
45
Database :
OpenAIRE
Journal :
Journal of Food Biochemistry
Accession number :
edsair.doi.dedup.....4a31aafdd3f0a47d3776d350e6071ad1
Full Text :
https://doi.org/10.1111/jfbc.13636