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Effect of intravenous testosterone on myocardial ischemia in men with coronary artery disease
- Source :
- American heart journal. 143(2)
- Publication Year :
- 2002
-
Abstract
- Background Studies on the effect of estrogen on atherosclerotic coronary artery disease (CAD) risk in women have produced conflicting results. Similar confusion, but fewer data, exists on the effect of testosterone on CAD risk in men. Methods We used 99mTc sestamibi single-photon emission computed tomography (SPECT) myocardial perfusion imaging to examine the acute effect of intravenous testosterone in 32 men (mean age, 69.1 ± 6.4 years) with provocable myocardial ischemia on standard medical therapy. Patients performed 3 exercise (n = 18) or adenosine (n = 16) stress tests during the infusion of placebo or 2 doses of testosterone designed to increase testosterone 2 or 6 times baseline. Results Serum testosterone increased 137 ± 58% and 488 ± 113%, and estradiol levels increased 27 ± 46% and 76 ± 57%, (P
- Subjects :
- Male
Technetium Tc 99m Sestamibi
medicine.medical_specialty
Myocardial Ischemia
Perfusion scanning
Placebo
Coronary artery disease
Myocardial perfusion imaging
Internal medicine
Heart rate
Medicine
Humans
Testosterone
Aged
Tomography, Emission-Computed, Single-Photon
medicine.diagnostic_test
business.industry
Testosterone (patch)
Middle Aged
medicine.disease
Endocrinology
Blood pressure
Cardiology
Radiopharmaceuticals
Cardiology and Cardiovascular Medicine
business
Perfusion
Subjects
Details
- ISSN :
- 10976744
- Volume :
- 143
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- American heart journal
- Accession number :
- edsair.doi.dedup.....4a30b2c8cd6f667a0a71d1b73f141953