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Combinational drug-loaded lipid nanocapsules for the treatment of cancer
- Source :
- International journal of pharmaceutics, Vol. 569, p. 118588 (2019)
- Publication Year :
- 2019
-
Abstract
- The purpose of this study was to investigate the feasibility of an intravenously administered combinational therapy using lipid nanocapsules (LNCs) as a drug delivery carrier for the treatment of different cancers. Therefore, we encapsulated 6 anticancer drugs within LNCs. Their size was approximately 50 nm. Except for oxaliplatin, their encapsulation efficiency, which was measured by different analytical methods, varied between 75% for SN38 to 100% for regorafenib. The in vitro studies showed a nonsignificant difference between the cytotoxicity of free and encapsulated drugs and a significant decrease in haemolysis by encapsulation in LNCs. Finally, the in vivo experiment showed that a combinational regimen of SN38-LNCs and regorafenib-LNCs abates CT26 murine colorectal cancer growth and increases median survival time.
- Subjects :
- Drug
Erythrocytes
Colorectal cancer
Pyridines
media_common.quotation_subject
Pharmaceutical Science
Antineoplastic Agents
02 engineering and technology
Pharmacology
Irinotecan
030226 pharmacology & pharmacy
Hemolysis
Lipid nanocapsules
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Nanocapsules
Regorafenib
Cell Line, Tumor
Neoplasms
medicine
Animals
Humans
Cytotoxicity
media_common
Mice, Inbred BALB C
Chemistry
Phenylurea Compounds
021001 nanoscience & nanotechnology
Haemolysis
medicine.disease
Lipids
Oxaliplatin
Regimen
SN38
Drug Combinations
Drug delivery
Female
0210 nano-technology
medicine.drug
Subjects
Details
- ISSN :
- 18733476
- Volume :
- 569
- Database :
- OpenAIRE
- Journal :
- International journal of pharmaceutics
- Accession number :
- edsair.doi.dedup.....4a2de6520ffbb5436658ba5e6e455926