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Evolving targets for anti-epileptic drug discovery
- Source :
- European journal of pharmacology. 887
- Publication Year :
- 2020
-
Abstract
- Epilepsy is a neurological disorder that affects almost 70 million people worldwide of all socioeconomic groups. The currently available medications aim to restore the balance between excitatory and inhibitory neurotransmitters by acting on ion channels, receptors, transporters, and enzymes, thus providing symptomatic relief. Though most of the patients receive a lasting remission however, 30% of patients are still pharmacoresistant. The incidence of adverse effects and associated comorbidities are also common. To overcome these challenges, researchers are focusing on the development of drugs based on novel targets and signaling cascades. This review summarizes several experimental findings that could be explored to identify potential targets for anti-epileptic drug discovery.
- Subjects :
- 0301 basic medicine
Pharmacology
Epilepsy
business.industry
Drug discovery
Drug Resistance
Neurological disorder
Bioinformatics
medicine.disease
Symptomatic relief
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Drug Discovery
Medicine
Animals
Humans
Anticonvulsants
business
Adverse effect
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18790712
- Volume :
- 887
- Database :
- OpenAIRE
- Journal :
- European journal of pharmacology
- Accession number :
- edsair.doi.dedup.....4a2d6b34b51b8b811bb8c94fd23cd5ea