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P53 deletion and NrasG12D cooperate for AML
- Source :
- Blood. 129:271-273
- Publication Year :
- 2017
- Publisher :
- American Society of Hematology, 2017.
-
Abstract
- In this issue of Blood, Zhang et al show the cooperation between P53 deletion and NRASG12D in the development of acute myeloid leukemia (AML). They also shed light on the megakaryocyte-erythroid progenitor (MEP) being the leukemia-initiating cell (LIC) targeted by P53 deletion and NRASG12D cooperation in mice.1
- Subjects :
- 0301 basic medicine
Myeloid
genetic structures
Bone marrow transplantation
Immunology
Cell
Biology
Biochemistry
03 medical and health sciences
hemic and lymphatic diseases
medicine
Humans
Gene
Sequence Deletion
Progenitor
Myeloid Neoplasia
Myeloid leukemia
Cell Biology
Hematology
Genes, p53
medicine.disease
Transplantation
Leukemia, Myeloid, Acute
Leukemia
030104 developmental biology
medicine.anatomical_structure
Cancer research
Tumor Suppressor Protein p53
Subjects
Details
- ISSN :
- 15280020 and 00064971
- Volume :
- 129
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi.dedup.....4a285a9ba2502f3c701cdd66926b735d