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Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment
- Source :
- Current opinion in chemical biology
- Publication Year :
- 2021
-
Abstract
- Targeting glutamine catabolism has been attracting more research attention on the development of successful cancer therapy. Catalytic enzymes such as glutaminase (GLS) in glutaminolysis, a series of biochemical reactions by which glutamine is converted to glutamate and then alpha-ketoglutarate, an intermediate of the tricarboxylic acid (TCA) cycle, can be targeted by small molecule inhibitors, some of which are undergoing early phase clinical trials and exhibiting promising safety profiles. However, resistance to glutaminolysis targeting treatments has been observed, necessitating the development of treatments to combat this resistance. One option is to use synergy drug combinations, which improve tumor chemotherapy's effectiveness and diminish drug resistance and side effects. This review will focus on studies involving the glutaminolysis pathway and diverse combination therapies with therapeutic implications.
- Subjects :
- 0301 basic medicine
Drug
Combination therapy
media_common.quotation_subject
Glutamine
Citric Acid Cycle
Antineoplastic Agents
Apoptosis
Drug resistance
010402 general chemistry
01 natural sciences
Biochemistry
Article
Analytical Chemistry
03 medical and health sciences
Glutaminase
Cell Line, Tumor
Antineoplastic Combined Chemotherapy Protocols
Medicine
Animals
Humans
Lactic Acid
Enzyme Inhibitors
Glutaminolysis
media_common
business.industry
Metabolic reprogramming
Therapeutic resistance
0104 chemical sciences
Cancer treatment
Clinical trial
030104 developmental biology
Drug Resistance, Neoplasm
Cancer research
Ketoglutaric Acids
Drug Screening Assays, Antitumor
business
Glycogen
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 18790402 and 13675931
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Current opinion in chemical biology
- Accession number :
- edsair.doi.dedup.....4a16522a7f6c459cb44ccb42c176d204