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Engineering Immunological Tolerance Using Quantum Dots to Tune the Density of SelfâAntigen Display
- Source :
- Advanced Functional Materials. 27:1700290
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Treatments for autoimmunity - diseases where the immune system mistakenly attacks self-molecules - are not curative and leave patients immunocompromised. New studies aimed at more specific treatments reveal development of inflammation or tolerance is influenced by the form self-antigens are presented. Using a mouse model of multiple sclerosis (MS), we show for the first time that quantum dots (QDs) can be used to generate immunological tolerance by controlling the density of self-antigen on QDs. These assemblies display dense arrangements of myelin self-peptide associated with disease in MS, are uniform in size (
- Subjects :
- 0301 basic medicine
Materials science
Nanotechnology
Inflammation
02 engineering and technology
medicine.disease_cause
Article
Autoimmunity
Biomaterials
03 medical and health sciences
Myelin
Immune system
Antigen
Electrochemistry
medicine
Scavenger receptor
Multiple sclerosis
technology, industry, and agriculture
equipment and supplies
021001 nanoscience & nanotechnology
Condensed Matter Physics
medicine.disease
3. Good health
Electronic, Optical and Magnetic Materials
Cell biology
030104 developmental biology
medicine.anatomical_structure
Quantum dot
medicine.symptom
0210 nano-technology
Subjects
Details
- ISSN :
- 16163028 and 1616301X
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Advanced Functional Materials
- Accession number :
- edsair.doi.dedup.....4a12cf99376559d6dcdb2493057ab10c