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Experimental Tityus serrulatus scorpion envenomation: age- and sex-related differences in symptoms and mortality in mice
- Source :
- Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 17, Issue: 3, Pages: 325-332, Published: 2011, Journal of Venomous Animals and Toxins including Tropical Diseases v.17 n.3 2011, The Journal of venomous animals and toxins including tropical diseases, Universidade Estadual Paulista (UNESP), instacron:UNESP, Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 17, Iss 3, Pp 325-332 (2011)
- Publication Year :
- 2011
- Publisher :
- Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP, 2011.
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Abstract
- Among the various methods for evaluating animal venom toxicity, the calculation of the median lethal dose (LD50) is the most widely used. Although different protocols can be used to calculate the LD50, the source of the venom and the method of extraction, as well as the strain, age, and sex of the animal model employed, should be taken into consideration. The objective of the present study was to evaluate the influence of sex and age on the toxicity of Tityus serrulatus scorpion venom in Swiss mice. Although the symptoms of envenomation were similar in male and female animals, female mice proved to be more resistant to the venom. In females, age had no impact on the susceptibility to scorpion envenomation. Male mice were more sensitive to T. serrulatus venom. Moreover, in males, age was an important parameter since sensitivity to the venom increased with age.
- Subjects :
- age factors
Tityus serrulatus
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962
Scorpion
Physiology
Male mice
Venom
Toxicology
Age and sex
Median lethal dose
complex mixtures
stings
lcsh:RA1190-1270
biology.animal
lcsh:Zoology
gender
lcsh:QL1-991
Envenomation
lcsh:Toxicology. Poisons
scorpions
biology
LD50
biology.organism_classification
Infectious Diseases
Immunology
Toxicity
Animal Science and Zoology
Parasitology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 17, Issue: 3, Pages: 325-332, Published: 2011, Journal of Venomous Animals and Toxins including Tropical Diseases v.17 n.3 2011, The Journal of venomous animals and toxins including tropical diseases, Universidade Estadual Paulista (UNESP), instacron:UNESP, Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 17, Iss 3, Pp 325-332 (2011)
- Accession number :
- edsair.doi.dedup.....4a0154aae4c8de1ac8da966dc4c7eb27