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Expression levels of IL-27 and IL-17 in multiple myeloma patients: a higher ratio of IL-27:IL-17 in bone marrow was associated with a superior progression-free survival
- Source :
- Leukemia research. 37(9)
- Publication Year :
- 2013
-
Abstract
- The goal of the study was to investigate the levels of interleukin-27 (IL-27) and IL-17 in bone marrow (BM) and peripheral blood (PB) of multiple myeloma (MM). The levels of IL-27 and IL-17 were determined in MM patients and controls using ELISA. The results showed a decreased IL-27 and elevated IL-17 level in MM patients and a negative association of IL-27 with IL-17. The ratio of IL-27:IL-17 in BM of newly diagnosed MM was significantly decreased and correlated with the progression of disease. Multivariate analysis showed that a higher ratio of IL-27:IL-17 in BM was associated with a superior progression-free survival (HR=0.160; 95% CI: 0.058-0.443; p
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
Negative association
Newly diagnosed
Gastroenterology
Bone Marrow
Internal medicine
medicine
Biomarkers, Tumor
Humans
Progression-free survival
Interleukin 27
Multiple myeloma
Neoplasm Staging
business.industry
Interleukins
Interleukin-17
Remission Induction
Hematology
Middle Aged
medicine.disease
Prognosis
Peripheral blood
Survival Rate
medicine.anatomical_structure
Oncology
Case-Control Studies
Immunology
Female
Interleukin 17
Bone marrow
business
Multiple Myeloma
Follow-Up Studies
Subjects
Details
- ISSN :
- 18735835
- Volume :
- 37
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Leukemia research
- Accession number :
- edsair.doi.dedup.....4a00639e01a9fdd7419de05e734b8659