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Recent Trends of Polymer Mediated Liposomal Gene Delivery System

Authors :
C. George Priya Doss
Garima Sharma
Ju-Suk Nam
Shin Yagihara
Shyamal Kumar Kundu
Sang-Soo Lee
Ashish Ranjan Sharma
Do-Young Kim
Chiranjib Chakraborty
Source :
BioMed Research International, Vol 2014 (2014), BIOMED RESEARCH INTERNATIONAL
Publication Year :
2014
Publisher :
Hindawi Limited, 2014.

Abstract

Advancement in the gene delivery system have resulted in clinical successes in gene therapy for patients with several genetic diseases, such as immunodeficiency diseases, X-linked adrenoleukodystrophy (X-ALD) blindness, thalassemia, and many more. Among various delivery systems, liposomal mediated gene delivery route is offering great promises for gene therapy. This review is an attempt to depict a portrait about the polymer based liposomal gene delivery systems and their future applications. Herein, we have discussed in detail the characteristics of liposome, importance of polymer for liposome formulation, gene delivery, and future direction of liposome based gene delivery as a whole.

Details

Language :
English
ISSN :
23146141 and 23146133
Volume :
2014
Database :
OpenAIRE
Journal :
BioMed Research International
Accession number :
edsair.doi.dedup.....49f12d9e1033820faccbf58decebb73a