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The molecular mechanics of mixed lineage leukemia
- Source :
- Oncogene. 35:5215-5223
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Mixed lineage leukemia caused by MLL fusion proteins is still a mostly incurable disease. Research on novel treatment strategies has gained momentum in the last years with the elucidation of the molecular mechanisms underlying the transforming potential of these powerful oncoproteins. This review summarizes the recent developments in this area including new attempts to treat MLL in a rational way by exploiting the biochemical vulnerabilities of the leukemogenic process.
- Subjects :
- 0301 basic medicine
Cancer Research
Oncogene Proteins, Fusion
Computational biology
Biology
Molecular mechanics
Molecular oncology
Leukemogenic
Small Molecule Libraries
Mice
03 medical and health sciences
MIXED LINEAGE LEUKEMIA
hemic and lymphatic diseases
Genetics
Animals
Humans
Molecular Targeted Therapy
Molecular Biology
health care economics and organizations
Leukemia
Histone-Lysine N-Methyltransferase
Methyltransferases
Fusion protein
Neoplasm Proteins
Gene Expression Regulation, Neoplastic
030104 developmental biology
Treatment strategy
Myeloid-Lymphoid Leukemia Protein
Subjects
Details
- ISSN :
- 14765594 and 09509232
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Oncogene
- Accession number :
- edsair.doi.dedup.....49ed899c8644fd8fb06af6625942fe85