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Chordin is under expressed in ovarian tumors and reduces tumor cells motility
- Source :
- FASEB Journal, FASEB Journal, Federation of American Society of Experimental Biology, 2006, 20, pp.240-250. ⟨10.1096/fj.05-4126com⟩
- Publication Year :
- 2006
- Publisher :
- HAL CCSD, 2006.
-
Abstract
- Ovarian cancers mostly derive from the monolayer epithelium that covers the ovary. There are currently very few molecular clues to the etiology of this cancer. Bone morphogenetic proteins (BMPs) are required for follicular development and female fertility and are expressed in the ovarian surface epithelium (OSE). We previously reported the expression of human chordin (CHRD), a BMP extracellular regulator, in the ovary. Here we show that CHRD is underexpressed in epithelium ovary cancer and epithelial cancer cell lines as compared with normal tissues and OSE, respectively. Besides, we detected BMP expression in all ovarian cell lines analyzed. To determine the functional relevance of the absence of CHRD mRNA in tumors and cancer cell lines, we studied the effects of CHRD on two cancer cell lines, BG1 and PEO14. Migratory and invasive properties were greatly reduced, whereas cell adhesion to the support was enhanced. In addition, we detected chordin (Chrd) expression in OSE of rat ovaries in a pattern similar to that of BMP4. Altogether, these results suggest that CHRD could participate in regulating BMP activity in normal OSE physiology, and that its mis-expression in OSE may facilitate cancer incidence and/or progression.
- Subjects :
- endocrine system
medicine.medical_specialty
Gene Dosage
Ovary
Biology
Bone morphogenetic protein
Biochemistry
03 medical and health sciences
0302 clinical medicine
Cell Movement
Ovarian carcinoma
Internal medicine
Cell Line, Tumor
Genetics
medicine
Cell Adhesion
Animals
Humans
Neoplasm Invasiveness
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Cell adhesion
Molecular Biology
030304 developmental biology
Glycoproteins
Regulation of gene expression
Ovarian Neoplasms
0303 health sciences
[SDV.GEN]Life Sciences [q-bio]/Genetics
Cancer
Epithelial Cells
medicine.disease
Epithelium
3. Good health
Rats
Gene Expression Regulation, Neoplastic
Ovarian Cysts
Endocrinology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cancer research
Intercellular Signaling Peptides and Proteins
Female
Chordin
Biotechnology
Subjects
Details
- Language :
- English
- ISSN :
- 08926638 and 15306860
- Database :
- OpenAIRE
- Journal :
- FASEB Journal, FASEB Journal, Federation of American Society of Experimental Biology, 2006, 20, pp.240-250. ⟨10.1096/fj.05-4126com⟩
- Accession number :
- edsair.doi.dedup.....49e4e9564336bbb148a0899e36320c60