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Anti-inflammatory effect of quetiapine on collagen-induced arthritis of mouse
- Source :
- European journal of pharmacology. 678(1-3)
- Publication Year :
- 2011
-
Abstract
- Quetiapine is an atypical antipsychotic and has also been used in the treatment of depression. Since anti-inflammatory effects of antidepressants are well established, we hypothesized that quetiapine may also exert anti-inflammatory effects. Thus this study was designed to examine the anti-inflammatory effect of quetiapine in murine collagen-induced arthritis. Mice were immunized with collagen type II for the induction of arthritis and treated with quetiapine (10mg/kg) daily for 2weeks. Mice were divided into 3 groups: control, CIA, and CIA+quetiapine treatment. Arthritic index and paw thickness were used to compare severity of arthritis. In additions, radiological and histological assessments were employed. Anti-type II collagen-specific antibody, interleukin-6 (IL-6), interleukin-17 (IL-17), and prostaglandin E(2) (PGE(2)) were evaluated at the end of the treatment period. Both arthritic index and paw thickness were markedly improved in CIA+quetiapine treatment group compared with those in CIA groups (arthritic index; P
- Subjects :
- musculoskeletal diseases
Male
medicine.medical_specialty
Dibenzothiazepines
medicine.drug_class
medicine.medical_treatment
Anti-Inflammatory Agents
Atypical antipsychotic
Arthritis
Inflammation
Anti-inflammatory
Antibodies
Bone and Bones
Dinoprostone
Arthritis, Rheumatoid
Mice
Quetiapine Fumarate
Internal medicine
medicine
Animals
Prostaglandin-E Synthases
Pharmacology
business.industry
Interleukin-6
Tumor Necrosis Factor-alpha
Body Weight
Interleukin-17
medicine.disease
Arthritis, Experimental
Intramolecular Oxidoreductases
Radiography
Endocrinology
Cartilage
Mice, Inbred DBA
Anesthesia
Rheumatoid arthritis
Quetiapine
medicine.symptom
business
Prostaglandin E
medicine.drug
Subjects
Details
- ISSN :
- 18790712
- Volume :
- 678
- Issue :
- 1-3
- Database :
- OpenAIRE
- Journal :
- European journal of pharmacology
- Accession number :
- edsair.doi.dedup.....49d5587e00e0f8ab263778f158053eda