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d4TMP Delivery from 7-SubstitutedcycloSal-d4TMPs
- Source :
- Nucleosides, Nucleotides and Nucleic Acids. 22:825-827
- Publication Year :
- 2003
- Publisher :
- Informa UK Limited, 2003.
-
Abstract
- Benzyl-substituted cycloSal-d4T monophosphates were prepared and evaluated for their ability to release d4TMP selectively. In contrast to previously reported derivatives, two of the new compounds release d4TMP as the sole product while two others gave the expected benzyl phosphate diesters. However, these diesters were surprisingly stable against degradation to release d4TMP.
Details
- ISSN :
- 15322335 and 15257770
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Nucleosides, Nucleotides and Nucleic Acids
- Accession number :
- edsair.doi.dedup.....49d3ca1cb9c64962ffa11b9064d575d1
- Full Text :
- https://doi.org/10.1081/ncn-120022663