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Thymoproteasome Shapes Immunocompetent Repertoire of CD8+ T Cells
- Source :
- Immunity. 32:29-40
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- SummaryHow self-peptides displayed in the thymus contribute to the development of immunocompetent and self-protective T cells is largely unknown. In contrast, the role of thymic self-peptides in eliminating self-reactive T cells and thereby preventing autoimmunity is well established. A type of proteasome, termed thymoproteasome, is specifically expressed by thymic cortical epithelial cells (cTECs) and is required for the generation of optimal cellularity of CD8+ T cells. Here, we show that cTECs displayed thymoproteasome-specific peptide-MHC class I complexes essential for the positive selection of major and diverse repertoire of MHC class I-restricted T cells. CD8+ T cells generated in the absence of thymoproteasomes displayed a markedly altered T cell receptor repertoire that was defective in both allogeneic and antiviral responses. These results demonstrate that thymoproteasome-dependent self-peptide production is required for the development of an immunocompetent repertoire of CD8+ T cells.
- Subjects :
- Proteasome Endopeptidase Complex
Immunology
Thymus Gland
CD8-Positive T-Lymphocytes
Biology
Lymphocyte Activation
medicine.disease_cause
Autoimmunity
Mice
T-Lymphocyte Subsets
MHC class I
medicine
Animals
Immunology and Allergy
Cytotoxic T cell
MOLIMMUNO
Mice, Knockout
Repertoire
Positive selection
Histocompatibility Antigens Class I
Cell Differentiation
Epithelial Cells
Cell biology
T-Cell Receptor Repertoire
Self Tolerance
Infectious Diseases
Proteasome
CELLIMMUNO
biology.protein
CD8
Subjects
Details
- ISSN :
- 10747613
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Immunity
- Accession number :
- edsair.doi.dedup.....49c9bf3029e0996cddf8855308bdd855