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Neuropsychological correlates of schizophrenic syndromes in patients treated with atypical neuroleptics
- Source :
- European psychiatry : the journal of the Association of European Psychiatrists. 16(6)
- Publication Year :
- 2001
-
Abstract
- SummaryThere is widespread evidence that schizophrenic symptomatology is best represented by three syndromes (positive, negative, disorganized). Both the disorganized and negative syndrome have been found to correlate with several neurocognitive dysfunctions. However, previous studies investigated samples predominantly treated with typical neuroleptics, which frequently induce parkinsonian symptoms that are hard to disentangle from primary negative symptoms and may have inflated correlations with neurocognition. A newly developed psychopathological instrument called the Positive and Negative and Disorganized Symptoms Scale (PANADSS) was evaluated in 60 schizophrenic patients. Forty-seven participants treated with atypical neuroleptics performed several neurocognitive tasks.A three-factor solution of schizophrenic symptomatology emerged. Negative symptomatology was associated with diminished creative verbal fluency and digit span backward, whereas disorganization was significantly correlated with impaired Stroop, WCST and Trail-Making Test B performance.Data suggest that disorganization is associated with tasks that demand executive functioning. Previous findings reporting correlations between negative symptomatology and neurocognition may have been confounded by the adverse consequences of typical neuroleptics.
- Subjects :
- Adult
Male
medicine.medical_specialty
Psychosis
media_common.quotation_subject
Neuropsychological Tests
Diagnosis, Differential
03 medical and health sciences
0302 clinical medicine
medicine
Memory span
Verbal fluency test
Humans
030212 general & internal medicine
Affective Symptoms
Psychiatry
media_common
Psychiatric Status Rating Scales
Schizophrenia, Disorganized
Neuropsychology
Middle Aged
medicine.disease
030227 psychiatry
Psychiatry and Mental health
Acute Disease
Schizophrenia
Female
Psychology
Neurocognitive
Psychopathology
Vigilance (psychology)
Stroop effect
Antipsychotic Agents
Subjects
Details
- ISSN :
- 09249338
- Volume :
- 16
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- European psychiatry : the journal of the Association of European Psychiatrists
- Accession number :
- edsair.doi.dedup.....49c31c8329c908e89f7cf0feb7853260