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1,3,5-Triazine-Based Mass Spectral Tagging of One-Bead One-Compound Libraries
- Source :
- Organic Letters. 9:171-173
- Publication Year :
- 2006
- Publisher :
- American Chemical Society (ACS), 2006.
-
Abstract
- A triazine-based mass encoding strategy that accommodates cleavable linker, isotopic labeling, and diversity receptor moieties is reported. The resulting triazine-based tags, which are coupled to bifunctionalized TentaGel resin in a one-pot transformation, enable the construction of a 1-oxa-2,8-diazaspiro[4.5]dec-2-ene-7-carboxamide library and facilitate decoding by equalizing the ionization potential of the liberated tags in single bead MALDI-TOF experiments as well as balancing the reactivity of the starting tags in the resin coupling step. [reaction: see text].
- Subjects :
- Aza Compounds
Molecular Structure
Triazines
Organic Chemistry
Stereoisomerism
Sensitivity and Specificity
Biochemistry
Combinatorial chemistry
Isotopic labeling
chemistry.chemical_compound
Tentagel resin
chemistry
1,3,5-Triazine
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Combinatorial Chemistry Techniques
Polystyrenes
Molecule
Spiro Compounds
Reactivity (chemistry)
Cleavable linker
Physical and Theoretical Chemistry
Triazine
One bead one compound
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....49bce60e5fe765c497c9a0e524e607d5