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Bioavailability of the antiemetic metopimazine given as a microenema
- Source :
- British journal of clinical pharmacology. 41(6)
- Publication Year :
- 1996
-
Abstract
- The absorption of the antiemetic metopimazine (MPZ) given as a single dose of (a) 40 mg microenema, (b) 40 mg orally and (c) 10 mg as a 60 min i.v. continuous infusion was investigated in six healthy volunteers. Blood samples were drawn and the serum concentrations of MPZ and its acid metabolite were measured. The bioavailability of MPZ given orally and as enemas was 22.3 and 19.5% respectively. Partial avoidance of hepatic first pass metabolism was seen with the enemas, which in contrast to suppositories, seems to represent a reliable form of rectal administration.
- Subjects :
- Adult
Male
medicine.drug_class
Administration, Oral
Biological Availability
Enema
Pharmacology
Intestinal absorption
First pass effect
Pharmacokinetics
Oral administration
Administration, Rectal
Isonipecotic Acids
medicine
Antiemetic
Humans
Pharmacology (medical)
Infusions, Intravenous
Metopimazine
business.industry
Original Articles
Middle Aged
Bioavailability
Intestinal Absorption
Rectal administration
Antiemetics
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 03065251
- Volume :
- 41
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- British journal of clinical pharmacology
- Accession number :
- edsair.doi.dedup.....49b647b9e13361d52eb8d6b8614f9d48