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Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response
- Source :
- Journal of Immunology Research, Vol 2019 (2019), Journal of Immunology Research
- Publication Year :
- 2019
- Publisher :
- Hindawi Limited, 2019.
-
Abstract
- High-altitude deacclimatization syndrome (HADAS) is involved in hypoxia-reoxygenation injury and inflammatory response, induced a series of symptoms, and has emerged as a severe public health issue. Here, we investigated the mechanism as well as potential means to prevent HADAS using Shenqi pollen capsules (SPCs) in subjects with HADAS in a multicenter, double-blinded, randomized, placebo-controlled study. All subjects were at the same high altitude (3650 m) for 4-8 months before returning to lower altitudes. Subjects (n=288) in 20 clusters were diagnosed with mild or moderate HADAS on the third day of the study. We randomly allocated 20 clusters of subjects (1 : 1) to receive SPCs or a placebo for 7 weeks, and they were then followed up to the 14th week. The primary endpoints were subjects’ HADAS scores recorded during the 14 weeks of follow-up. Compared with the placebo, SPC treatment significantly decreased the subjects’ HADAS scores and reduced the incidence of symptom persistence. SPC therapy also reduced the serum levels of CK, CK-MB, LDH, IL-17A, TNF-α, and miR-155 and elevated IL-10 and miR-21 levels. We thus demonstrate that SPCs effectively ameliorated HADAS symptoms in these subjects via suppression of the hypoxia-reoxygenation injury and inflammatory response.
- Subjects :
- Male
Acclimatization
Treatment outcome
Anti-Inflammatory Agents
Gene Expression
Gastroenterology
law.invention
0302 clinical medicine
Randomized controlled trial
law
Immunology and Allergy
Hypoxia
0303 health sciences
Incidence (epidemiology)
Altitude
Interleukin-17
General Medicine
Syndrome
Effects of high altitude on humans
Interleukin-10
Treatment Outcome
030220 oncology & carcinogenesis
Symptom persistence
medicine.symptom
Casein Kinases
Research Article
Adult
lcsh:Immunologic diseases. Allergy
medicine.medical_specialty
Adolescent
Article Subject
Inflammatory response
Immunology
Inflammation
Capsules
Placebo
03 medical and health sciences
Double-Blind Method
Internal medicine
medicine
Humans
030304 developmental biology
L-Lactate Dehydrogenase
business.industry
Tumor Necrosis Factor-alpha
Oxygen
MicroRNAs
business
lcsh:RC581-607
Drugs, Chinese Herbal
Subjects
Details
- Language :
- English
- ISSN :
- 23147156 and 23148861
- Volume :
- 2019
- Database :
- OpenAIRE
- Journal :
- Journal of Immunology Research
- Accession number :
- edsair.doi.dedup.....49afe7a53f451a79865c98ebae1680fe