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Glucocorticoid exposure in early placentation induces preeclampsia in rats via interfering trophoblast development
- Source :
- General and comparative endocrinology. 225
- Publication Year :
- 2015
-
Abstract
- In pregnancy, placenta can be exposed to glucocorticoids (GCs) via several ways, which may disturb placentation and adversely affect pregnancy. Preeclampsia (PE) is thought to be attributed, in part, to impaired trophoblast development. The purpose of the present study was to confirm that GC exposure in early placentation could lead to PE in rats, with the mechanisms involving dysregulated trophoblast development. In the study, pregnant rats were administered with 2.5mg/kg Dex subcutaneously once per day from gestational day 7 to 13. Maternal systolic blood pressure and urinary albumin were increased, while both fetus and placenta were restricted after GC exposure relative to the control group. GC exposure also contributed to placental abnormalities and renal impairment. Moreover, placental oxidative damage was increased along with placental hypoxia-inducible factor 1-alpha (HIF1A) overexpression after GC treatment. Mechanically, GC induced PE in rat partially through inhibiting trophoblast proliferation, migration, invasion and epithelial-mesenchymal transition (EMT), which involved phospho-extracellular signal regulated kinase (p-ERK) downregulation. Furthermore, GC receptor was required for the inhibition of GC on trophoblast proliferation, migration, invasion and EMT in vitro. These findings suggest that GC exposure in early placentation could contribute to PE in pregnant rats, with the mechanisms involving inhibition of trophoblast proliferation, migration, invasion and EMT by GC.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Placenta
Down-Regulation
Biology
Dexamethasone
Preeclampsia
03 medical and health sciences
Endocrinology
Downregulation and upregulation
Pre-Eclampsia
Pregnancy
Internal medicine
medicine
Animals
Epithelial–mesenchymal transition
Glucocorticoids
reproductive and urinary physiology
Fetus
Trophoblast
Placentation
medicine.disease
Hypoxia-Inducible Factor 1, alpha Subunit
Rats
Trophoblasts
Oxidative Stress
030104 developmental biology
medicine.anatomical_structure
embryonic structures
Animal Science and Zoology
Female
Glucocorticoid
medicine.drug
Subjects
Details
- ISSN :
- 10956840
- Volume :
- 225
- Database :
- OpenAIRE
- Journal :
- General and comparative endocrinology
- Accession number :
- edsair.doi.dedup.....49a6de8300cc36d043c82305b3580963