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Unravelling the Role of LncRNA WT1-AS/miR-206/NAMPT Axis as Prognostic Biomarkers in Lung Adenocarcinoma
- Source :
- Biomolecules, Biomolecules, Vol 11, Iss 203, p 203 (2021), Volume 11, Issue 2
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Lung cancer is the world’s highest morbidity and mortality of malignant tumors, with lung adenocarcinoma (LUAD) as a major subtype. The competitive endogenous RNA (ceRNA) regulative network provides opportunities to understand the relationships among different molecules, as well as the regulative mechanisms among them in order to investigate the whole transcriptome landscape in cancer pathology. We designed this work to explore the role of a key oncogene, MYC, in the pathogenesis of LUAD, and this study aims to identify important long noncoding RNA (lncRNA)-microRNA (miRNA)- transcription factor (TF) interactions in non-small cell lung cancer (NSCLC) using a bioinformatics analysis. The Cancer Genome Atlas (TCGA) database, containing mRNA expression data of NSCLC, was used to determine the deferentially expressed genes (DEGs), and the ceRNA network was composed of WT1-AS, miR-206, and nicotinamide phosphoribosyltransferase (NAMPT) bashing on the MYC expression level. The Kaplan–Meier univariate survival analysis showed that these components may be closely related prognostic biomarkers and will become new ideas for NSCLC treatment. Moreover, the high expression of WT1-AS and NAMPT and low expression of miR-206 were associated with a shortened survival in NSCLC patients, which provided a survival advantage. In summary, the current study constructing a ceRNA-based WT1-AS/miR-206/NAMPT axis might be a novel important prognostic factor associated with the diagnosis and prognosis of LUAD.
- Subjects :
- 0301 basic medicine
LUAD
Male
ceRNA network
Lung Neoplasms
Databases, Factual
WT1-AS/miR-206/NAMPT axis
lcsh:QR1-502
Kaplan-Meier Estimate
Biology
Adenocarcinoma
Biochemistry
lcsh:Microbiology
Article
Transcriptome
03 medical and health sciences
0302 clinical medicine
Carcinoma, Non-Small-Cell Lung
microRNA
medicine
Biomarkers, Tumor
Humans
Lung cancer
Nicotinamide Phosphoribosyltransferase
Molecular Biology
Aged
Oncogene
Competing endogenous RNA
Genome, Human
Sequence Analysis, RNA
Gene Expression Profiling
Cancer
Computational Biology
Middle Aged
medicine.disease
Prognosis
Long non-coding RNA
MicroRNAs
030104 developmental biology
030220 oncology & carcinogenesis
Cancer research
Cytokines
Female
RNA, Long Noncoding
Software
Subjects
Details
- Language :
- English
- ISSN :
- 2218273X
- Volume :
- 11
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Biomolecules
- Accession number :
- edsair.doi.dedup.....4995e249b09f6c831ff79901da02a3cc