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Nucleic acid sensing by T cells initiates Th2 cell differentiation
- Source :
- Nature communications. 5
- Publication Year :
- 2013
-
Abstract
- While T-cell responses are directly modulated by Toll-like receptor (TLR) ligands, the mechanism and physiological function of nucleic acids (NAs)-mediated T cell costimulation remains unclear. Here we show that unlike in innate cells, T-cell costimulation is induced even by non-CpG DNA and by self-DNA, which is released from dead cells and complexes with antimicrobial peptides or histones. Such NA complexes are internalized by T cells and induce costimulatory responses independently of known NA sensors, including TLRs, RIG-I-like receptors (RLRs), inflammasomes and STING-dependent cytosolic DNA sensors. Such NA-mediated costimulation crucially induces Th2 differentiation by suppressing T-bet expression, followed by the induction of GATA-3 and Th2 cytokines. These findings unveil the function of NA sensing by T cells to trigger and amplify allergic inflammation.
- Subjects :
- Chromatin Immunoprecipitation
Cellular differentiation
Antimicrobial peptides
General Physics and Astronomy
Enzyme-Linked Immunosorbent Assay
Biology
Real-Time Polymerase Chain Reaction
General Biochemistry, Genetics and Molecular Biology
Allergic inflammation
Mice
Th2 Cells
RNA interference
Nucleic Acids
Animals
Receptor
Multidisciplinary
Microscopy, Confocal
Cell Differentiation
General Chemistry
T-Lymphocytes, Helper-Inducer
Molecular biology
Cell biology
Mice, Inbred C57BL
Cytosol
Histone
Nucleic acid
biology.protein
RNA Interference
Subjects
Details
- ISSN :
- 20411723
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Nature communications
- Accession number :
- edsair.doi.dedup.....498d8a036162635be9ab5d0b9e3d8b1e