Back to Search
Start Over
An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS
- Source :
- International Journal of Environmental Research and Public Health, Volume 18, Issue 2, International Journal of Environmental Research and Public Health, Vol 18, Iss 767, p 767 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- Lead (Pb) is a metal toxicant of great public health concern. The present study investigated the applicability of the rat incisor in Pb exposure screening. The levels of lead in teeth (Pb-T) in the crown and root of incisors in laboratory Pb-exposed Sprague Dawley rats were quantified using inductively coupled plasma mass spectrometry (ICP-MS). The crown accumulated much Pb-T than the root of the Sprague Dawley rat incisor. The levels of lead in blood (Pb-B) were positively correlated with the Pb-T in the crown and root incisors of the Sprague Dawley rats. As an application of the Pb-T crown results in experimental rats, we subsequently analyzed the Pb-T in the crown incisors of Pb-exposed wild rats (Rattus rattus) sampled from residential sites within varying distances from an abandoned lead&ndash<br />zinc mine. The Pb-T accumulation in the crown of incisors of R. rattus rats decreased with increased distance away from the Pb&ndash<br />Zn mine. Furthermore, the Pb-T was strongly correlated (r = 0.85) with the Pb levels in the blood. Laser ablation ICP-MS Pb-T mappings revealed a homogenous distribution of Pb in the incisor with an increased intensity of Pb-T localized in the tip of the incisor crown bearing an enamel surface in both Sprague Dawley and R. rattus rats. These findings suggest that Pb-T in the crown incisor may be reflective of the rat&rsquo<br />s environmental habitat, thus a possible indicator of Pb exposure.
- Subjects :
- Health, Toxicology and Mutagenesis
medicine.medical_treatment
lcsh:Medicine
010501 environmental sciences
Mass spectrometry
01 natural sciences
Article
Mass Spectrometry
Crown (dentistry)
Rats, Sprague-Dawley
Plasma
03 medical and health sciences
0302 clinical medicine
Animal science
Incisor
stomatognathic system
medicine
Animals
incisor
sentinel
Inductively coupled plasma mass spectrometry
0105 earth and related environmental sciences
lead
Laser ablation
Enamel paint
Chemistry
wild rodent
lcsh:R
Public Health, Environmental and Occupational Health
030206 dentistry
Rats
Sprague dawley
stomatognathic diseases
medicine.anatomical_structure
visual_art
visual_art.visual_art_medium
biomarker
Rat incisor
Laser Therapy
Subjects
Details
- Language :
- English
- ISSN :
- 16604601
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health
- Accession number :
- edsair.doi.dedup.....4985e6b34d3e744e68d5ae7361456040
- Full Text :
- https://doi.org/10.3390/ijerph18020767