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Permanent grafting of living skin substitutes: surgical parameters to control for successful results
- Source :
- The Journal of burn carerehabilitation. 17(1)
- Publication Year :
- 1996
-
Abstract
- Autologous mesh grafting, widely used in the treatment of severe burns, remains the most conventional approach for permanent skin replacement. However, during the last decade several types of skin substitutes were reported as suitable alternatives for full-thickness burn wound coverage. The clinical use of such dressings requires new surgical skills to maintain the integrity of the grafts and favor their permanent implantation in vivo. This article reports observations made on nude mice grafted with cultured human skin equivalents. Some parameters such as the quality of adhesion between the implant and the graft bed, the size, the stability and the thickness of the graft, the humidity of the chamber, and the protocol of antibiotic administration were identified as crucial for the success of the surgery. The grafting procedures are described in this paper. These results should be taken into consideration in all transplantations of skin grafts in vivo.
- Subjects :
- Male
medicine.medical_specialty
Grafting (decision trees)
Transplantation, Heterologous
Adhesion (medicine)
Mice, Nude
Human skin
Mice
In vivo
Culture Techniques
Skin substitutes
Medicine
Animals
Humans
Severe burn
General Nursing
Skin, Artificial
Burn wound
integumentary system
business.industry
Rehabilitation
Graft Survival
Skin Transplantation
medicine.disease
Surgery
Disease Models, Animal
surgical procedures, operative
General Health Professions
Emergency Medicine
Implant
business
Burns
Subjects
Details
- ISSN :
- 02738481
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Journal of burn carerehabilitation
- Accession number :
- edsair.doi.dedup.....498334344b2fe2b5b99820767584738b