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Cooperation between STAT3 and c-Jun Suppresses Fas Transcription

Authors :
Laurie B. Owen-Schaub
Vladimir N. Ivanov
Regina Raz
David E. Levy
Ze'ev Ronai
Mikhail Krasilnikov
Curt M. Horvath
Anindita Bhoumik
Publication Year :
2001
Publisher :
Columbia University, 2001.

Abstract

Decreased Fas expression during tumor progression often results in a loss of Fas-ligand (FasL)-mediated apoptosis. Human and mouse melanoma exhibit an inverse correlation between the degree of Fas cell surface expression, tumorigenicity, and metastatic capacity. The expression of dominant negative Stat3 or c-Jun in melanoma cells efficiently increased Fas expression and sensitized cells to FasL-induced apoptosis. Stat3+/- as well as c-Jun-/- cells exhibited increased Fas cell surface expression and higher sensitivity to FasL-mediated apoptosis. Suppression of Fas expression by Stat3 and c-Jun is uncoupled from Stat3-mediated transcriptional activation. Our findings indicate that Stat3 oncogenic activities could also be mediated through its cooperation with c-Jun, resulting in downregulation of Fas surface expression, which is implicated in the tumor's ability to resist therapy and metastasize.

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....4979af9ddb2e08650b1969deb397cbb9
Full Text :
https://doi.org/10.7916/d80k27t9