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Cooperation between STAT3 and c-Jun Suppresses Fas Transcription
- Publication Year :
- 2001
- Publisher :
- Columbia University, 2001.
-
Abstract
- Decreased Fas expression during tumor progression often results in a loss of Fas-ligand (FasL)-mediated apoptosis. Human and mouse melanoma exhibit an inverse correlation between the degree of Fas cell surface expression, tumorigenicity, and metastatic capacity. The expression of dominant negative Stat3 or c-Jun in melanoma cells efficiently increased Fas expression and sensitized cells to FasL-induced apoptosis. Stat3+/- as well as c-Jun-/- cells exhibited increased Fas cell surface expression and higher sensitivity to FasL-mediated apoptosis. Suppression of Fas expression by Stat3 and c-Jun is uncoupled from Stat3-mediated transcriptional activation. Our findings indicate that Stat3 oncogenic activities could also be mediated through its cooperation with c-Jun, resulting in downregulation of Fas surface expression, which is implicated in the tumor's ability to resist therapy and metastasize.
- Subjects :
- STAT3 Transcription Factor
Transcriptional Activation
Fas Ligand Protein
Transcription, Genetic
Proto-Oncogene Proteins c-jun
Ultraviolet Rays
Cell
Apoptosis
Response Elements
Radiation Tolerance
Fas ligand
Mice
Downregulation and upregulation
Tumor Cells, Cultured
medicine
Animals
Humans
RNA, Messenger
fas Receptor
Promoter Regions, Genetic
STAT3
Molecular Biology
Melanoma
Sequence Deletion
Regulation of gene expression
Membrane Glycoproteins
biology
c-jun
Cancer cells--Growth
DNA
Cell Biology
Fibroblasts
Up-Regulation
Cell biology
DNA-Binding Proteins
Transcription Factor AP-1
medicine.anatomical_structure
Gene Expression Regulation
Oncology
Tumor progression
Trans-Activators
biology.protein
Cancer research
Cytology
Protein Binding
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....4979af9ddb2e08650b1969deb397cbb9
- Full Text :
- https://doi.org/10.7916/d80k27t9