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Pathogenic B‐cell receptor signaling in lymphoid malignancies: New insights to improve treatment
- Source :
- Immunol Rev
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Signals emanating from the B cell receptor (BCR) promote proliferation and survival in diverse forms of B cell lymphoma. Precision medicine strategies targeting the BCR pathway have been generally effective in treating lymphoma, but often fail to produce durable responses in diffuse large B cell lymphoma (DLBCL), a common and aggressive cancer. New insights into DLBCL biology garnered from genomic analyses and functional proteogenomic studies have identified novel modes of BCR signaling in this disease. Herein, we describe the distinct roles of antigen-dependent and antigen-independent BCR signaling in different subtypes of DLBCL. We highlight mechanisms by which the BCR cooperates with TLR9 and mutant isoforms of MYD88 to drive sustained NF-κB activity in the activated B cell-like (ABC) subtype of DLBCL. Finally, we discuss progress in detecting and targeting oncogenic BCR signaling to improve the survival of patients with lymphoma.
- Subjects :
- 0301 basic medicine
Lymphoma
Immunology
B-cell receptor
Receptors, Antigen, B-Cell
Disease
Biology
Autoantigens
Article
03 medical and health sciences
0302 clinical medicine
immune system diseases
hemic and lymphatic diseases
medicine
Animals
Humans
Immunology and Allergy
Receptor
breakpoint cluster region
TLR9
Cancer
Germinal Center
medicine.disease
Leukemia, Lymphoid
Cell Transformation, Neoplastic
030104 developmental biology
Cancer research
Signal transduction
Signal Transduction
030215 immunology
Subjects
Details
- ISSN :
- 1600065X and 01052896
- Volume :
- 291
- Database :
- OpenAIRE
- Journal :
- Immunological Reviews
- Accession number :
- edsair.doi.dedup.....497384abcca3c2668542bdc663b1f376