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Fragmentation of diketopiperazines from Aspergillus fumigatus by electrospray ionization tandem mass spectrometry (ESI-MS/MS)
- Source :
- Journal of mass spectrometry : JMS. 42(10)
- Publication Year :
- 2007
-
Abstract
- Diketopiperazines (DKPs) corresponding to cyclic dipeptides have been reported to exhibit antimicrobial, antitumor, antimutagenic and antiviral properties. These compounds are commonly isolated from microorganisms and sponges and from a variety of tissues and body fluids. In this work, we used electrospray ionization tandem mass spectrometry (ESI-MS/MS) to investigate the fragmentation of a series of DKPs previously isolated from Aspergillus fumigatus, which exhibit the same structural core. Loss of CO directly from the protonated molecule was found to be a fragmentation process common to all the compounds analyzed. However, our results revealed a series of ions that are diagnostic for the substituents at C(4) and C(9). In order to rationalize the differences in the fragmentation pathways of substituted and nonsubstituted DKPs, the relative Gibbs energies (1G) of the product ions and intermediate ions were estimated using the B3LYP/6‐31++G(d,p) model. The data reported here can be used for the structural elucidation of DKPs from low sample amounts, as an alternative to NMR. Copyright 2007 John Wiley & Sons, Ltd.
- Subjects :
- chemistry.chemical_classification
Electrospray
Spectrometry, Mass, Electrospray Ionization
biology
Molecular Structure
Chemistry
Stereochemistry
Electrospray ionization
Aspergillus fumigatus
Diketopiperazines
Tandem mass spectrometry
biology.organism_classification
Cyclic peptide
Fragmentation (mass spectrometry)
Tandem Mass Spectrometry
Molecule
Spectroscopy
Subjects
Details
- ISSN :
- 10765174
- Volume :
- 42
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of mass spectrometry : JMS
- Accession number :
- edsair.doi.dedup.....4970f2ad7febab9a27f6ed77b480c533