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Genetic resistance to malaria in mouse models
- Source :
- Trends in Parasitology. 21:352-355
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Murine models have proved to be excellent tools in the support of studies of the human genetic bases of malaria resistance and have enabled the mapping of 12 resistance loci, eight of them controlling parasitic levels and four controlling cerebral malaria. Further studies using this method have identified a Pklr variant that confers resistance to murine malaria, a result that shows the potential of this approach to aid the understanding of mechanisms of disease resistance. In the future, the use of murine models for genetic resistance to malaria could lead to the identification of relevant genetic factors that control this devastating disease.
- Subjects :
- Plasmodium
Genetic resistance
Genetic Linkage
Disease
Quantitative trait locus
Biology
Plant disease resistance
Parasitemia
Mice
Quantitative Trait, Heritable
Genetic linkage
parasitic diseases
medicine
Animals
Humans
Genetic Predisposition to Disease
Genetics
medicine.disease
biology.organism_classification
Malaria
Disease Models, Animal
Infectious Diseases
Cerebral Malaria
Parasitology
Subjects
Details
- ISSN :
- 14714922
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Trends in Parasitology
- Accession number :
- edsair.doi.dedup.....49641005a6775f2caa5a1b485848dfb2