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Case Report: A Case of Primaquine-Induced Hemoglobinuria in Glucose-6-Phosphate Dehydrogenase Deficient Malaria Patient in Southeastern Bangladesh
- Source :
- Am J Trop Med Hyg
- Publication Year :
- 2019
-
Abstract
- We herein report the first case of Mediterranean glucose-6-phosphate dehydrogenase (G6PD) variant from Bangladesh. A boy had been admitted to hospital and was diagnosed with uncomplicated Plasmodium vivax infection and treated with 30 mg/kg body weight (BW) chloroquine for 3 days and 4.8 mg/kg BW primaquine (PQ) to be taken over 14 days. The boy was discharged but represented 4 days later with severe hemoglobinuria and fatigue. Hemoglobin was measured at 6.0 g/dL and serum bilirubin was at 5.6 mg/dL, although malaria microscopy was negative. The boy had taken the 4-fold recommended daily dose of PQ and was treated with two fresh blood transfusions. Subsequent molecular analysis showed the boy to have the Mediterranean G6PD variant and a G6PD activity of 0.93 U/gHb.
- Subjects :
- Male
medicine.medical_specialty
Blood transfusion
Primaquine
medicine.medical_treatment
G6PD activity
030231 tropical medicine
Hemoglobinuria
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
Antimalarials
0302 clinical medicine
Chloroquine
Virology
Internal medicine
parasitic diseases
medicine
Glucose-6-phosphate dehydrogenase
Humans
Blood Transfusion
Child
business.industry
Articles
medicine.disease
Malaria
Infectious Diseases
Glucosephosphate Dehydrogenase Deficiency
chemistry
Parasitology
Hemoglobin
business
medicine.drug
Subjects
Details
- ISSN :
- 14761645
- Volume :
- 102
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The American journal of tropical medicine and hygiene
- Accession number :
- edsair.doi.dedup.....495c20e5ad1dd83c8f3b56133493846b