Back to Search
Start Over
Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descent
- Source :
- Drug metabolism and disposition: the biological fate of chemicals. 32(12)
- Publication Year :
- 2004
-
Abstract
- A polymorphism for the phase I drug-metabolizing enzyme, flavin-containing monooxygenase isoform 2 (FMO2), encoding either truncated inactive protein, FMO2X472 (FMO2.2A), or full-length active enzyme, FMO2Q472 (FMO2.1), is known and exhibits significant interethnic differences in allelic frequency. FMO2 is the major or sole FMO isoform expressed in the lung of most mammals, including nonhuman primates. To date, FMO2.1 has been found only in African-American and Hispanic populations, rendering individuals with this allele subject to drug metabolism that is potentially different from that of the general population. Approximately 26% of African-Americans (n = 180) possess the FMO2*1 allele. In preliminary studies, we initially estimated that 5% of Hispanics (n = 40) have the FMO2*1 allele, but access to large cohorts of individuals of defined national origin has allowed us to determine the occurrence among Mexican-American and Puerto Rican-American groups. We used allele-specific genotyping to detect FMO2*1 from 632 Hispanic individuals, including 280 individuals of Mexican origin and 327 individuals of Puerto Rican origin. Statistical analysis indicated that results from Mexican (five sample sources) and Puerto Rican (three sample sources) samples were consistent with the hypothesis of homogeneity within each group from different sources. Data were subsequently pooled across sources to test for evidence of a difference in occurrence of FMO2*1 between ethnic groups. There was strong evidence (p = 0.0066) that FMO2*1 is more common among Puerto Ricans (7%) than among individuals of Mexican descent (2%). The overall occurrence of FMO2*1 among Hispanics of all origins is estimated to be between 2 and 7%.
- Subjects :
- Genotype
Population
Ethnic group
Pharmaceutical Science
Biology
Cohort Studies
Gene Frequency
Occupational Exposure
Mexican Americans
Humans
Allele
education
Allele frequency
Genotyping
Alleles
Pharmacology
Genetics
education.field_of_study
Reverse Transcriptase Polymerase Chain Reaction
Environmental exposure
DNA
Environmental Exposure
Hispanic or Latino
United States
Isoenzymes
Pharmaceutical Preparations
Oxygenases
Cohort study
Subjects
Details
- ISSN :
- 00909556
- Volume :
- 32
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Drug metabolism and disposition: the biological fate of chemicals
- Accession number :
- edsair.doi.dedup.....495c0bfda9778ea6ea710df985ec7d15