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Clinical Implications of Lysyl Oxidase-Like Protein 2 Expression in Pancreatic Cancer
- Source :
- Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018), Scientific Reports
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group, 2018.
-
Abstract
- Lysyl oxidase (LOX) family genes, particularly lysyl oxidase-like protein 2 (LOXL2), have been implicated in carcinogenesis, metastasis, and the epithelial-to-mesenchymal transition (EMT) in various cancers. This study aimed to explore the clinical implications of LOXL2 expression in pancreatic cancer (PC) in the context of EMT status. LOX family mRNA expression was measured in PC cell lines, and LOXL2 protein levels were examined in surgical specimens resected from 170 patients with PC. Higher LOXL2 expression was observed in cell lines from mesenchymal type PC than in those from epithelial type PC. A significant correlation between LOXL2 expression and the EMT status defined based on the expression of E-cadherin and vimentin was observed in surgical specimens (P P P = 0.03) was a significant independent prognostic factor for patients with PC. Additionally, LOX inhibition significantly decreased PC cell proliferation, migration, and invasion in vitro. In conclusion, LOXL2 expression is potentially associated with PC progression, and LOXL2 expression represents a biomarker for predicting the prognosis of patients with PC who have undergone complete resection.
- Subjects :
- Male
0301 basic medicine
lcsh:Medicine
Apoptosis
Vimentin
medicine.disease_cause
Metastasis
Cohort Studies
0302 clinical medicine
Cell Movement
Tumor Cells, Cultured
lcsh:Science
Aged, 80 and over
Regulation of gene expression
Multidisciplinary
biology
LOXL2
Middle Aged
Prognosis
Gene Expression Regulation, Neoplastic
Survival Rate
030220 oncology & carcinogenesis
Disease Progression
Female
Amino Acid Oxidoreductases
Adult
Epithelial-Mesenchymal Transition
Lysyl oxidase
Article
Gene Expression Regulation, Enzymologic
03 medical and health sciences
Pancreatic cancer
Biomarkers, Tumor
medicine
Humans
Neoplasm Invasiveness
Epithelial–mesenchymal transition
Aged
Cell Proliferation
business.industry
lcsh:R
medicine.disease
Pancreatic Neoplasms
030104 developmental biology
biology.protein
Cancer research
lcsh:Q
business
Carcinogenesis
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....495baf2cdcad536c5c987458daa5c218