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Ride the wave:Retrograde trafficking becomes Ca(2+) dependent with BAIAP3
- Source :
- Sørensen, J B 2017, ' Ride the wave : Retrograde trafficking becomes Ca(2+) dependent with BAIAP3 ', Journal of Cell Biology, vol. 216, no. 7, pp. 1887-1889 . https://doi.org/10.1083/jcb.201706007, The Journal of Cell Biology
- Publication Year :
- 2017
-
Abstract
- The functions of four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as priming factors in SNARE-dependent exocytosis. In this issue, Zhang et al. show that the fifth member, BAIAP3, acts in retrograde trafficking by returning secretory vesicle material to the TGN. In its absence, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosomal vesicle degradation.<br />The functions of four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as priming factors in SNARE-dependent exocytosis. In this issue, Zhang et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702099) show that the fifth member, BAIAP3 (brain-specific angiogenesis inhibitor I–associated protein 3), acts in retrograde trafficking by returning secretory vesicle material to the trans-Golgi network. In its absence, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosomal vesicle degradation.
- Subjects :
- 0301 basic medicine
Cell
Priming (immunology)
Biology
Exocytosis
03 medical and health sciences
symbols.namesake
medicine
Journal Article
Animals
Spotlight
030102 biochemistry & molecular biology
Vesicle
Secretory Vesicles
Munc-18
Cell Biology
Golgi apparatus
Secretory Vesicle
Cell biology
Transport protein
Protein Transport
030104 developmental biology
medicine.anatomical_structure
symbols
Commentary
SNARE Proteins
trans-Golgi Network
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Sørensen, J B 2017, ' Ride the wave : Retrograde trafficking becomes Ca(2+) dependent with BAIAP3 ', Journal of Cell Biology, vol. 216, no. 7, pp. 1887-1889 . https://doi.org/10.1083/jcb.201706007, The Journal of Cell Biology
- Accession number :
- edsair.doi.dedup.....495a25bc4f7f1e605ed56ef0d24b3b47