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Plasma Levels of Adrenomedullin in Patients with Acute Myocardial Infarction
- Source :
- Clinical Science. 94:135-139
- Publication Year :
- 1998
- Publisher :
- Portland Press Ltd., 1998.
-
Abstract
- 1. Adrenomedullin, a newly identified vasorelaxant peptide, participates in the regulation of the cardiovascular system. To investigate the pathophysiological significance of adrenomedullin in patients with acute myocardial infarction, we measured plasma levels of adrenomedullin. 2. Cardiac catheterization was performed on admission, after 1 day, and after 4 weeks in 36 patients with acute myocardial infarction. We measured plasma levels of adrenomedullin, atrial natriuretic peptide and brain natriuretic peptide in the right atrium, pulmonary artery and aorta. 3. Plasma levels of adrenomedullin in the right atrium (mean ± SEM) were significantly increased on admission (4.2 ± 2.6 h) in patients with acute myocardial infarction (10.6 ± 1.0 pmol/l) compared with controls (5.2 ± 0.3 pmol/l, P < 0.01). In addition, plasma levels of adrenomedullin were further elevated in patients with congestive heart failure (12.3 ± 1.4 pmol/l) compared with patients without congestive heart failure (7.8 ± 0.6 pmol/l, P < 0.01). In patients with congestive heart failure, plasma adrenomedullin on admission significantly correlated with atrial natriuretic peptide and brain natriuretic peptide. 4. These results suggest that plasma adrenomedullin increases in the early phase of acute myocardial infarction and that volume expansion may be one of the additional stimuli for the release of adrenomedullin in patients with acute myocardial infarction complicated by congestive heart failure.
- Subjects :
- Adult
Male
medicine.medical_specialty
Vasodilator Agents
Myocardial Infarction
Nerve Tissue Proteins
Pulmonary Artery
Adrenomedullin
Atrial natriuretic peptide
Internal medicine
medicine.artery
Natriuretic Peptide, Brain
Blood plasma
medicine
Humans
Heart Atria
Myocardial infarction
Aorta
Aged
Aged, 80 and over
Heart Failure
business.industry
General Medicine
Middle Aged
medicine.disease
Brain natriuretic peptide
Endocrinology
Heart failure
Pulmonary artery
Cardiology
Female
Peptides
business
Atrial Natriuretic Factor
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 14708736 and 01435221
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Clinical Science
- Accession number :
- edsair.doi.dedup.....4953248a691a23ecde21654ed7094c40