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Increased body fat percentage in patients with hepatitis B and C virus infection
- Source :
- PLoS ONE, PLoS ONE, Vol 13, Iss 7, p e0200164 (2018)
- Publication Year :
- 2018
-
Abstract
- Accumulated evidence has suggested associations between glucose abnormalities and insulin resistance with hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. However, few studies have reported the effect of hepatitis virus infections on body composition. Our aim was to explore the association of hepatitis virus infections with percent body fat (PBF) in a cross-sectional analysis. A total of 69226 subjects obtained from the health examinations at Tri-Service General Hospital (TSGH) from 2010 to 2016 were enrolled in the study. Participants were divided into subgroups based on the presence of hepatitis B surface antigen (HBsAg) and anti-HCV. PBF was measured by bioelectrical impedance analysis (BIA). A multivariable linear regression model was applied to test the association of hepatitis virus infections with PBF and glycemic status. In male participants, hepatitis virus infections were closely associated with increased PBF, especially in those subjects with HCV/HBV coinfection. HCV/HBV coinfection was positively correlated with fasting plasma glucose and postprandial glucose while HCV and HBV mono-infection were not. The impact of hepatitis virus infection on increased PBF was observed in general population with gender difference. A further study on the treatment of hepatitis virus infection might help prevent the development of obesity-related diseases.
- Subjects :
- 0301 basic medicine
Blood Glucose
Male
RNA viruses
HBsAg
Physiology
lcsh:Medicine
Hepacivirus
medicine.disease_cause
Gastroenterology
Biochemistry
0302 clinical medicine
Endocrinology
Glucose Metabolism
lcsh:Science
Pathology and laboratory medicine
Multidisciplinary
Anthropometry
Coinfection
Hepatitis C virus
virus diseases
Hepatitis C
Hepatitis B
Middle Aged
Medical microbiology
Infectious Diseases
Adipose Tissue
Viruses
Body Composition
Carbohydrate Metabolism
030211 gastroenterology & hepatology
Female
Pathogens
Anatomy
Research Article
Adult
medicine.medical_specialty
Hepatitis B virus
Microbiology
Virus
03 medical and health sciences
F Factor
Internal medicine
medicine
Humans
Hepatitis
Medicine and health sciences
Hepatitis B Surface Antigens
Biology and life sciences
Flaviviruses
Endocrine Physiology
lcsh:R
Organisms
Viral pathogens
Hepatitis C Antibodies
medicine.disease
digestive system diseases
Hepatitis viruses
Microbial pathogens
030104 developmental biology
Cross-Sectional Studies
Metabolism
Biological Tissue
Co-Infections
lcsh:Q
Insulin Resistance
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 13
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....494f5e0565459304e7be74cd5ad13632