Molecular characterization and antibiogram profile of Acromobacter xylosoxidans isolated from human dental plaque sample in Dinajpur district, Bangladesh

Our research was conducted to investigate the currency and causative agents of dental carries with antibiotic sensitivity tests in Tasmia dental clinics, Saidpur, Nilphamari of Bangladesh. A total of 200 suspecting patients (20 to above 60 years old) were selected, standard bacteriological methods and molecular techniques were applied in this research. Out of overall patients, 55.83% had dental caries located at molar teeth, 27.5% between molar and premolar, 12.5% at incisor, and 4.17% at cervical margin. Dental caries was (P0.05) rate than male (53.95%) patients. Dental caries was significantly (PStaphylococcus spp. (33.33%), followed by E. coli (25.0%), Streptococcus spp. (20.0%), Acromobacter xylosoxidans (16.67%), and Pseudomonas spp. (5.0%), respectively. Acromobacter_ xylosoxidans_strain_LMG_1863 was identified with 144bp in this research. Antibiotic sensitivity test revealed that A. xylosoxidans and E. coli were resistant to more than six antibiotics where Pseudomonas spp were resistant except Ciprofloxacin and colistin. A frightening situation was that many Staphylococcus and Streptococcus species bacteria were extremely resistant to 4, 5, and more than six antibiotics, respectively. Toothpaste containing triclosan and fluoride, as an alternative to antibiotics, can help prevent dental cavities.