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Presumed tuberculosis-induced retinal vasculitis, diagnosed with positron emission tomography (18F-FDG-PET/CT), aspiration biopsy, and culture
- Source :
- Ocular immunology and inflammation. 18(3)
- Publication Year :
- 2010
-
Abstract
- The diagnosis of tuberculosis as an etiological factor in patients with uveitis is difficult because of lack of specific diagnostic tests. The authors report 2 cases of occlusive retinal vasculitis, in which (18)F-FDG-PET/CT was helpful for the diagnosis of tuberculosis as a presumptive cause of intraocular inflammation.In 2 patients with severe occlusive retinal vasculitis and positive QuantiFERON TB-Gold test, (18)F-FDG-PET/CT, transbronchial needle-aspiration biopsy, and microbiological investigation were performed.(18)F-FDG-PET/CT showed increased fluorodeoxyglucose uptake in some mediastinal and hilar lymph nodes. After needle-aspiration biopsy of PET-positive lymph nodes, M. tuberculosis was recovered in culture in both cases. Remission of uveitis was achieved only after a combination therapy with 3 anti-tubercular agents and systemic steroids.The authors favor the use of (18)F-FDG-PET/CT in patients with sight-threatening intraocular inflammation and positive interferon-gamma release assay. Anti-tubercular therapy, together with anti-inflammatory treatment, may lead to a remission in such patients.
- Subjects :
- Adult
DNA, Bacterial
Male
medicine.medical_specialty
Pathology
Tuberculosis
Fundus Oculi
Tuberculosis, Ocular
Polymerase Chain Reaction
QuantiFERON
Diagnosis, Differential
Fluorodeoxyglucose F18
Biopsy
medicine
Immunology and Allergy
Humans
Fluorescein Angiography
Fluorodeoxyglucose
Retinal Vasculitis
PET-CT
medicine.diagnostic_test
business.industry
Retinal vasculitis
Biopsy, Needle
Mediastinum
Mycobacterium tuberculosis
medicine.disease
Ophthalmology
Positron-Emission Tomography
Radiology
Lymph Nodes
Radiopharmaceuticals
business
Vasculitis
Uveitis
medicine.drug
Subjects
Details
- ISSN :
- 17445078
- Volume :
- 18
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Ocular immunology and inflammation
- Accession number :
- edsair.doi.dedup.....492df8310b992fed60af32136608cd95