Back to Search
Start Over
Glycodelin expression in pregnant patients with cervical intraepithelial neoplasia: a case-control study
- Source :
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 32(4)
- Publication Year :
- 2015
-
Abstract
- We aimed to evaluate glycodelin immunostaining in pregnant women with a first diagnosis of cervical intraephitelial neoplasia (CIN) and to correlate the expression of CIN with Ki-67 and glycodelin immunostaining. A retrospective case-control study was performed including 20 patients with natural pregnancy and with first time onset of CIN occurring not later than 16 gestational weeks. The control group included 20 non-pregnant patients matched for age, parity, smoking status and number of previous sexual partners. Exclusion criteria included previous cervical treatment, immunocompromised status and chronic hepatitis B and/or C. Staining for Glycodelin and for Ki-67 was expressed using a classification based on the distribution of positivity on a semi-quantitative three-point scale. An inverse relationship was observed between glycodelin immunostaining and CIN grade in pregnant patients (p = 0.01), with a significantly higher expression in CIN1 than in CIN2 and CIN3, but not in non-pregnant patients (p = 0.81). Positivity for Ki-67 was less intense in pregnant than in non-pregnant patients. A significant inverse relationship was observed between glycodelin immunostaining and Ki-67 expression (p = 0.02). We suggest that the higher expression of glycodelin in pregnancy is related to a lower proliferative activity in CIN, which is probably associated to hormonal status of pregnancy. Further clinical studies are needed to support these findings.
- Subjects :
- Adult
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Uterine Cervical Neoplasms
Cervical intraepithelial neoplasia
03 medical and health sciences
0302 clinical medicine
Endocrinology
Pregnancy
medicine
Humans
Retrospective Studies
Gynecology
030219 obstetrics & reproductive medicine
biology
Glycodelin
business.industry
Case-control study
Obstetrics and Gynecology
Retrospective cohort study
medicine.disease
Uterine Cervical Dysplasia
female genital diseases and pregnancy complications
Ki-67 Antigen
030220 oncology & carcinogenesis
Ki-67
biology.protein
Female
business
Pregnancy Complications, Neoplastic
Immunostaining
Hormone
Subjects
Details
- ISSN :
- 14730766
- Volume :
- 32
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
- Accession number :
- edsair.doi.dedup.....492bfdd04dfd112a35fc611c776dfc9c